Mitochondrial Dysfunction and Autism ~ New Research

In 2013, we consulted with Dr. Richard Frye and Dr. Stephen Kahler and their research team at Arkansas Children’s Hospital in Little Rock and our daughter took part in a Mitochondrial Disease Research Study.  It was comforting to be in a place with practitioners who really “got it”, specifically intricacies of the medical complexities of the  kids. It was also reassuring to know there is a dedicated team of doctors and researchers actively seeking answers as to the connections between mitochondrial disease, autism and environmental oxidative stressors.  The paper below, which was published this week, is the first of many more to come, I am confident, on the groundbreaking technology used to show that in a subset of autistic children there are “significant abnormalities in mitochondrial respiration before and after exposure to increasing reactive oxygen species.”

Key Take Home Message:  “This study suggests that a significant subgroup of AD (autistic disorder) children may have alterations in mitochondrial function which could render them more vulnerable to a pro-oxidant microenvironment derived from intrinsic and extrinsic sources of ROS (reactive oxygen species) such as immune activation and pro-oxidant environmental toxicants.”


Oxidative Stress Induces Mitochondrial Dysfunction in a Subset of Autism Lymphoblastoid Cell Lines in a Well-Matched Case Control Cohort

Full text of the article can be found HERE.

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